99 peer-reviewed papers, 1998 to today

Rodriguez F, Saeij JPJ

Sensing the enemy within: Vγ9Vδ2 T cells as metabolic sensors of intracellular parasites

Trends Parasitol 2026; 42(9): 846-860PubMed

Cruz-Miron R, Swale C, Liang Q, Yamaryo-Botté Y, Arnold CS, Hakimi MA, Botté CY, Bougdour A, Saeij JPJ

TgSEC14-LTP1 is a vacuole-secreted SEC14/CRAL-TRIO-like protein required for host DAG flux and PC homeostasis in T. gondii

Cell Rep 2026; 45(5): 117299PubMedFree full text

Rodriguez F, Saeij JPJ

The early human interferon gamma response to Toxoplasma gondii is driven by Vγ9Vδ2 T-cell sensing of host phosphoantigens and subsequent NK-cell activation

PLoS Pathog 2025; 21(12): e1013829PubMedFree full text

Bitew MA, Paredes-Santos TC, Maru P, Krishnamurthy S, Wang Y, Sangaré LO, Duley S, Yamaryo-Botté Y, Botté CY, Saeij JPJ

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions

Nat Commun 2025; 16(1): 11177PubMedFree full text

Morales P, Kramer DA, de Moraes de Siqueira C, Brown AJ, Sangaré LO, Chen B, Saeij JPJ

Toxoplasma effector TgWIP hijacks dendritic cell actin and motility via Nck1/Grb2 and the WAVE complex

mBio 2025; 16(12): e0187425PubMedFree full text

Sinnott DM, Miller M, Arranz-Solís D, Rodriguez F, Saeij JPJ, Batac F, Greenwald K, Young C, Harris MD, Gomes M, Shapiro K

Fatal Toxoplasma gondii COUG strain infections in southern sea otters (Enhydra lutris nereis): New insight on contributing factors and parasite serotyping

PLoS One 2025; 20(9): e0332223PubMedFree full text

Cohen O, Maru P, Liang Q, Saeij JPJ

Surface antigen SAG1 mediates Toxoplasma gondii fitness and host cell attachment in IFNγ-stimulated cells

Infect Immun 2025; 93(8): e0001025PubMedFree full text

Ten Hoeve AL, Rodriguez ME, Säflund M, Michel V, Magimel L, Ripoll A, Yu T, Hakimi M-A, Saeij JPJ, Ozata DM, Barragan A

Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates Toxoplasma dissemination

mBio 2024; 15(10): e0214024PubMedFree full text

Morales P, Brown AJ, Sangaré LO, Yang S, Kuihon SVNP, Chen B, Saeij JPJ

The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2

Cell Mol Life Sci 2024; 81(1): 294PubMedFree full text

Gupta P, Hiller A, Chowdhury J, Lim D, Lim DY, Saeij JPJ, Babaian A, Rodriguez F, Pereira L, Morales-Tapia A

A parasite odyssey: An RNA virus concealed in Toxoplasma gondii

Virus Evol 2024; 10(1): veae040PubMedFree full text

Bitew MA, Gaete PS, Swale C, Maru P, Contreras JE, Saeij JPJ

Two Toxoplasma gondii putative pore-forming proteins, GRA47 and GRA72, influence small molecule permeability of the parasitophorous vacuole

mBio 2024; 15(3): e0308123PubMedFree full text

Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ

Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity

mBio 2024; 15(3): e0330223PubMedFree full text

Paredes-Santos TC, Bitew MA, Swale C, Rodriguez F, Krishnamurthy S, Wang Y, Maru P, Sangaré LO, Saeij JPJ

Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma

PLoS Pathog 2023; 19(7): e1011543PubMedFree full text

Krishnamurthy S, Maru P, Wang Y, Bitew MA, Mukhopadhyay D, Yamaryo-Botté Y, Paredes-Santos TC, Sangaré LO, Swale C, Botté CY, Saeij JPJ

CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells

mBio 2023; 14(2): e0006023PubMedFree full text

Arranz-Solís D, Warschkau D, Fabian BT, Seeber F, Saeij JPJ

Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses

mBio 2023; 14(2): e0286822PubMedFree full text

Gonzales-Viera O, Arranz-Solís D, Smith J, Saeij JPJ, Mete A

Fatal Sarcocystis calchasi hepatitis in a captive Indian ringneck parakeet (Psittacula krameri manillensis)

Vet Parasitol Reg Stud Reports 2023; 39: 100841PubMed

Ten Hoeve AL, Braun L, Rodriguez ME, Olivera GC, Bougdour A, Belmudes L, Couté Y, Saeij JPJ, Hakimi MA, Barragan A

The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages

Cell Host Microbe 2022; 30(11): 1570-1588.e7PubMedFree full text

Rico-San Román L, Amieva R, Regidor-Cerrillo J, García-Sánchez M, Collantes-Fernández E, Pastor-Fernández I, Saeij JPJ, Ortega-Mora LM, Horcajo P

NcGRA7 and NcROP40 Play a Role in the Virulence of Neospora caninum in a Pregnant Mouse Model

Pathogens 2022; 11(9)PubMedFree full text

Ross EC, Hoeve ALT, Saeij JPJ, Barragan A

Toxoplasma effector-induced ICAM-1 expression by infected dendritic cells potentiates transmigration across polarised endothelium

Front Immunol 2022; 13: 950914PubMedFree full text

Arranz-Solís D, Saeij JPJ

New Avenues to Design Toxoplasma Vaccines Based on Oocysts and Cysts

Front Immunol 2022; 13: 910961PubMedFree full text

Rogers KH, Arranz-Solís D, Saeij JPJ, Lewis S, Mete A

Sarcocystis calchasi and other Sarcocystidae detected in predatory birds in California, USA

Int J Parasitol Parasites Wildl 2022; 17: 91-99PubMedFree full text

Glausen TG, Carrillo GL, Jin RM, Boyle JP, Saeij JPJ, Wohlfert EA, Fox MA, Blader IJ

The Toxoplasma Polymorphic Effector GRA15 Mediates Seizure Induction by Modulating Interleukin-1 Signaling in the Brain

mBio 2021; 12(3): e0133121PubMedFree full text

Tomita T, Mukhopadhyay D, Han B, Yakubu R, Tu V, Mayoral J, Sugi T, Ma Y, Saeij JPJ, Weiss LM

Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector

mBio 2021; 12(3)PubMedFree full text

Sangaré LO, Wang Y, Arranz-Solís D, Saeij JPJ

CRISPR screen to determine the in vivo fitness of Toxoplasma genes

STAR Protoc 2021; 2(2): 100520PubMedFree full text

Arranz-Solís D, Carvalheiro CG, Zhang ER, Grigg ME, Saeij JPJ

Toxoplasma GRA Peptide-Specific Serologic Fingerprints Discriminate Among Major Strains Causing Toxoplasmosis

Front Cell Infect Microbiol 2021; 11: 621738PubMedFree full text

Arranz-Solís D, Mukhopadhyay D, Saeij JJP

Toxoplasma Effectors that Affect Pregnancy Outcome

Trends Parasitol 2021; 37(4): 283-295PubMedFree full text

Wang Y, Sangaré LO, Paredes-Santos TC, Hassan MA, Krishnamurthy S, Furuta AM, Markus BM, Lourido S, Saeij JPJ

Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages

Nat Commun 2020; 11(1): 5258PubMedFree full text

Mukhopadhyay D, Arranz-Solís D, Saeij JPJ

Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection

Front Cell Infect Microbiol 2020; 10: 580425PubMedFree full text

Kongsomboonvech AK, Rodriguez F, Diep AL, Justice BM, Castallanos BE, Camejo A, Mukhopadhyay D, Taylor GA, Yamamoto M, Saeij JPJ, Reese ML, Jensen KDC

Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5

PLoS Pathog 2020; 16(8): e1008327PubMedFree full text

Wang Y, Sangaré LO, Paredes-Santos TC, Saeij JPJ

Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface

Annu Rev Microbiol 2020; 74: 567-586PubMedFree full text

Bamac OE, Rogers KH, Arranz-Solís D, Saeij JPJ, Lewis S, Duerr R, Skoglund J, Peronne L, Mete A

Protozoal encephalitis associated with Sarcocystis calchasi and S. falcatula during an epizootic involving Brandt's cormorants (Phalacrocorax penicillatus) in coastal Southern California, USA

Int J Parasitol Parasites Wildl 2020; 12: 185-191PubMedFree full text

Mukhopadhyay D, Arranz-Solís D, Saeij JPJ

Toxoplasma GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11

PLoS Pathog 2020; 16(5): e1008586PubMedFree full text

Rico-San Román L, Horcajo P, Regidor-Cerrillo J, Fernández-Escobar M, Collantes-Fernández E, Gutiérrez-Blázquez D, Hernáez-Sánchez ML, Saeij JPJ, Ortega-Mora LM

Comparative tachyzoite proteome analyses among six Neospora caninum isolates with different virulence

Int J Parasitol 2020; 50(5): 377-388PubMed

Mukhopadhyay D, Sangaré LO, Braun L, Hakimi MA, Saeij JP

Toxoplasma GRA15 limits parasite growth in IFNγ-activated fibroblasts through TRAF ubiquitin ligases

EMBO J 2020; 39(10): e103758PubMedFree full text

Waldman BS, Schwarz D, Wadsworth MH, Saeij JP, Shalek AK, Lourido S

Identification of a Master Regulator of Differentiation in Toxoplasma

Cell 2020; 180(2): 359-372.e16PubMedFree full text

Mukhopadhyay D, Saeij JPJ

Assays to Evaluate Toxoplasma-Macrophage Interactions

Methods Mol Biol 2020; 2071: 347-370PubMedFree full text

Arranz-Solís D, Cordeiro C, Young LH, Dardé ML, Commodaro AG, Grigg ME, Saeij JPJ

Serotyping of Toxoplasma gondii Infection Using Peptide Membrane Arrays

Front Cell Infect Microbiol 2019; 9: 408PubMedFree full text

Sangaré LO, Ólafsson EB, Wang Y, Yang N, Julien L, Camejo A, Pesavento P, Sidik SM, Lourido S, Barragan A, Saeij JPJ

In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration

Cell Host Microbe 2019; 26(4): 478-492.e8PubMedFree full text

Paredes-Santos T, Wang Y, Waldman B, Lourido S, Saeij JP

The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability

Front Cell Infect Microbiol 2019; 9: 321PubMedFree full text

Sangaré LO, Yang N, Konstantinou EK, Lu D, Mukhopadhyay D, Young LH, Saeij JPJ

Toxoplasma GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors

mBio 2019; 10(4)PubMedFree full text

Wang Y, Cirelli KM, Barros PDC, Sangaré LO, Butty V, Hassan MA, Pesavento P, Mete A, Saeij JPJ

Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

mBio 2019; 10(1)PubMedFree full text

Hassan MA, Olijnik AA, Frickel EM, Saeij JP

Clonal and atypical Toxoplasma strain differences in virulence vary with mouse sub-species

Int J Parasitol 2019; 49(1): 63-70PubMedFree full text

Krishnamurthy S, Saeij JPJ

Toxoplasma Does Not Secrete the GRA16 and GRA24 Effectors Beyond the Parasitophorous Vacuole Membrane of Tissue Cysts

Front Cell Infect Microbiol 2018; 8: 366PubMedFree full text

Arranz-Solís D, Regidor-Cerrillo J, Lourido S, Ortega-Mora LM, Saeij JPJ

Toxoplasma CRISPR/Cas9 constructs are functional for gene disruption in Neospora caninum

Int J Parasitol 2018; 48(8): 597-600PubMedFree full text

Saeij JP, Frickel EM

Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death

Curr Opin Microbiol 2017; 40: 72-80PubMedFree full text

Krishnamurthy S, Konstantinou EK, Young LH, Gold DA, Saeij JP

The human immune response to Toxoplasma: Autophagy versus cell death

PLoS Pathog 2017; 13(3): e1006176PubMedFree full text

Sidik SM, Huet D, Ganesan SM, Huynh MH, Wang T, Nasamu AS, Thiru P, Saeij JPJ, Carruthers VB, Niles JC, Lourido S

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

Cell 2016; 166(6): 1423-1435.e12PubMedFree full text

Fink A, Hassan MA, Okan NA, Sheffer M, Camejo A, Saeij JP, Kasper DL

Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19

mBio 2016; 7(2): e02243PubMedFree full text

Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij JP, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD

Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes

Nat Commun 2016; 7: 10147PubMedFree full text

Hassan MA, Jensen KD, Butty V, Hu K, Boedec E, Prins P, Saeij JP

Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection

PLoS Genet 2015; 11(10): e1005619PubMedFree full text

Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP

The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole

Cell Host Microbe 2015; 17(5): 642-52PubMedFree full text

Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij JP

Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination

mBio 2015; 6(2): e02280PubMedFree full text

Hassan MA, Saeij JP

Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits

Bioessays 2014; 36(11): 1032-40PubMedFree full text

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA

Macrophage activation and polarization: nomenclature and experimental guidelines

Immunity 2014; 41(1): 14-20PubMedFree full text

Cirelli KM, Gorfu G, Hassan MA, Printz M, Crown D, Leppla SH, Grigg ME, Saeij JP, Moayeri M

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii

PLoS Pathog 2014; 10(3): e1003927PubMedFree full text

Cannella D, Brenier-Pinchart MP, Braun L, van Rooyen JM, Bougdour A, Bastien O, Behnke MS, Curt RL, Curt A, Saeij JP, Sibley LD, Pelloux H, Hakimi MA

miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain

Cell Rep 2014; 6(5): 928-37PubMedFree full text

Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME

Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii

mBio 2014; 5(1)PubMedFree full text

Rosowski EE, Nguyen QP, Camejo A, Spooner E, Saeij JP

Toxoplasma gondii Inhibits gamma interferon (IFN-γ)- and IFN-β-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA

Infect Immun 2014; 82(2): 706-19PubMedFree full text

Hassan MA, Butty V, Jensen KD, Saeij JP

The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages

Genome Res 2014; 24(3): 377-89PubMedFree full text

Camejo A, Gold DA, Lu D, McFetridge K, Julien L, Yang N, Jensen KD, Saeij JP

Identification of three novel Toxoplasma gondii rhoptry proteins

Int J Parasitol 2014; 44(2): 147-60PubMedFree full text

Melo MB, Nguyen QP, Cordeiro C, Hassan MA, Yang N, McKell R, Rosowski EE, Julien L, Butty V, Dardé ML, Ajzenberg D, Fitzgerald K, Young LH, Saeij JP

Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways

PLoS Pathog 2013; 9(12): e1003779PubMedFree full text

Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP

Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence

J Biol Chem 2013; 288(48): 34968-80PubMedFree full text

Niedelman W, Sprokholt JK, Clough B, Frickel EM, Saeij JP

Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication

Infect Immun 2013; 81(12): 4341-9PubMedFree full text

Yang N, Farrell A, Niedelman W, Melo M, Lu D, Julien L, Marth GT, Gubbels MJ, Saeij JP

Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains

BMC Genomics 2013; 14: 467PubMedFree full text

Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij JP

Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15

Infect Immun 2013; 81(6): 2156-67PubMedFree full text

Hassan MA, Melo MB, Haas B, Jensen KD, Saeij JP

De novo reconstruction of the Toxoplasma gondii transcriptome improves on the current genome annotation and reveals alternatively spliced transcripts and putative long non-coding RNAs

BMC Genomics 2012; 13: 696PubMedFree full text

Rosowski EE, Saeij JP

Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylation

PLoS One 2012; 7(12): e51448PubMedFree full text

Minot S, Melo MB, Li F, Lu D, Niedelman W, Levine SS, Saeij JP

Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity

Proc Natl Acad Sci U S A 2012; 109(33): 13458-63PubMedFree full text

Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JP

The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response

PLoS Pathog 2012; 8(6): e1002784PubMedFree full text

Szatanek T, Anderson-White BR, Faugno-Fusci DM, White M, Saeij JP, Gubbels MJ

Cactin is essential for G1 progression in Toxoplasma gondii

Mol Microbiol 2012; 84(3): 566-77PubMedFree full text

Lim DC, Cooke BM, Doerig C, Saeij JP

Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling

Int J Parasitol 2012; 42(1): 21-32PubMedFree full text

Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM

Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it

PLoS One 2011; 6(9): e24434PubMedFree full text

Melo MB, Jensen KD, Saeij JP

Toxoplasma gondii effectors are master regulators of the inflammatory response

Trends Parasitol 2011; 27(11): 487-95PubMedFree full text

Jensen KD, Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong YC, Chien YH, Hunter CA, Boothroyd JC, Saeij JP

Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation

Cell Host Microbe 2011; 9(6): 472-83PubMedFree full text

Reese ML, Zeiner GM, Saeij JP, Boothroyd JC, Boyle JP

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence

Proc Natl Acad Sci U S A 2011; 108(23): 9625-30PubMedFree full text

Rosowski EE, Lu D, Julien L, Rodda L, Gaiser RA, Jensen KD, Saeij JP

Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein

J Exp Med 2011; 208(1): 195-212PubMedFree full text

Blader IJ, Saeij JP

Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence

APMIS 2009; 117(5-6): 458-76PubMedFree full text

Boyle JP, Saeij JP, Harada SY, Ajioka JW, Boothroyd JC

Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression

Eukaryot Cell 2008; 7(8): 1403-14PubMedFree full text

Saeij JP, Arrizabalaga G, Boothroyd JC

A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence

Infect Immun 2008; 76(6): 2402-10PubMedFree full text

Boyle JP, Saeij JP, Boothroyd JC

Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice

Exp Parasitol 2007; 116(3): 302-5PubMed

Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC

Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue

Nature 2007; 445(7125): 324-7PubMedFree full text

Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC

Polymorphic secreted kinases are key virulence factors in toxoplasmosis

Science 2006; 314(5806): 1780-3PubMedFree full text

Boyle JP, Rajasekar B, Saeij JPJ, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC

Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii

Proc Natl Acad Sci U S A 2006; 103(27): 10514-10519PubMedFree full text

Boyle JP, Saeij JP, Cleary MD, Boothroyd JC

Analysis of gene expression during development: lessons from the Apicomplexa

Microbes Infect 2006; 8(6): 1623-30PubMed

Huttenhuis HB, Taverne-Thiele AJ, Grou CP, Bergsma J, Saeij JP, Nakayasu C, Rombout JH

Ontogeny of the common carp (Cyprinus carpio L.) innate immune system

Dev Comp Immunol 2006; 30(6): 557-74PubMed

Saeij JP, Boyle JP, Boothroyd JC

Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host

Trends Parasitol 2005; 21(10): 476-81PubMed

Saeij JP, Boyle JP, Grigg ME, Arrizabalaga G, Boothroyd JC

Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains

Infect Immun 2005; 73(2): 695-702PubMedFree full text

Joerink M, Saeij JP, Stafford JL, Belosevic M, Wiegertjes GF

Animal models for the study of innate immunity: protozoan infections in fish

Symp Soc Exp Biol 2004(55): 67-89; discussion 243-5PubMed

Saeij JP, Groeneveld A, Van Rooijen N, Haenen OL, Wiegertjes GF

Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates

Dis Aquat Organ 2003; 57(1-2): 67-75PubMed

Saeij JP, de Vries BJ, Wiegertjes GF

The immune response of carp to Trypanoplasma borreli: kinetics of immune gene expression and polyclonal lymphocyte activation

Dev Comp Immunol 2003; 27(10): 859-74PubMed

Engelsma MY, Stet RJ, Saeij JP, Verburg-van Kemenade BM

Differential expression and haplotypic variation of two interleukin-1beta genes in the common carp (Cyprinus carpio L.)

Cytokine 2003; 22(1-2): 21-32PubMed

Saeij JP, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF

Daily handling stress reduces resistance of carp to Trypanoplasma borreli: in vitro modulatory effects of cortisol on leukocyte function and apoptosis

Dev Comp Immunol 2003; 27(3): 233-45PubMed

Saeij JP, van Muiswinkel WB, van de Meent M, Amaral C, Wiegertjes GF

Different capacities of carp leukocytes to encounter nitric oxide-mediated stress: a role for the intracellular reduced glutathione pool

Dev Comp Immunol 2003; 27(6-7): 555-68PubMed

Saeij JP, Stet RJ, de Vries BJ, van Muiswinkel WB, Wiegertjes GF

Molecular and functional characterization of carp TNF: a link between TNF polymorphism and trypanotolerance?

Dev Comp Immunol 2003; 27(1): 29-41PubMed

Saeij JP, Van Muiswinkel WB, Groeneveld A, Wiegertjes GF

Immune modulation by fish kinetoplastid parasites: a role for nitric oxide

Parasitology 2002; 124(Pt 1): 77-86PubMed

Saeij JP, Stet RJ, Groeneveld A, Verburg-van Kemenade LB, van Muiswinkel WB, Wiegertjes GF

Molecular and functional characterization of a fish inducible-type nitric oxide synthase

Immunogenetics 2000; 51(4-5): 339-46PubMed

Saeij JP, Wiegertjes GF, Stet RJ

Identification and characterization of a fish natural resistance-associated macrophage protein (NRAMP) cDNA

Immunogenetics 1999; 50(1-2): 60-6PubMed

Stet RJ, Kruiswijk CP, Saeij JP, Wiegertjes GF

Major histocompatibility genes in cyprinid fishes: theory and practice

Immunol Rev 1998; 166: 301-16PubMed

Verburg-Van Kemenade BM, Saeij JP, Flik G, Willems PH

Ca2+ signals during early lymphocyte activation in carp Cyprinus carpio L

J Exp Biol 1998; 201(Pt 4): 591-8PubMed